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Thursday
Altered cells deliver Parkinson's therapy to brain
Genetically modified nerve 'progenitor' cells can be used as mini-pumps to deliver nerve growth factor to the brain, a new study in animals shows.
The results suggest such an approach could be used to treat Parkinson's disease and other brain diseases in humans, Dr. Clive D. Svendsen of the University of Wisconsin-Madison and colleagues report.
A nerve growth factor called "glial cell line-derived neurotrophic factor" (abbreviated to GDNF) has been shown to protect dopamine-producing neurons, which are lost in Parkinson's disease, Svendsen and his team note in the research journal Gene Therapy.
In fact, it's safe to infuse GDNF into brain regions of patients with Parkinson's disease, according to some studies, and it seems effective. However, delivering the drug in this fashion is complex and only reaches a single point in the brain. more| Reuters.com
The results suggest such an approach could be used to treat Parkinson's disease and other brain diseases in humans, Dr. Clive D. Svendsen of the University of Wisconsin-Madison and colleagues report.
A nerve growth factor called "glial cell line-derived neurotrophic factor" (abbreviated to GDNF) has been shown to protect dopamine-producing neurons, which are lost in Parkinson's disease, Svendsen and his team note in the research journal Gene Therapy.
In fact, it's safe to infuse GDNF into brain regions of patients with Parkinson's disease, according to some studies, and it seems effective. However, delivering the drug in this fashion is complex and only reaches a single point in the brain. more| Reuters.com