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Wednesday
Botox Soothes Overactive Bladder
[ABSTRACT: CME Teaching Brief - MedPage Today]
"....Botox (botulinum toxin type A) injected directly into the bladder's detrusor muscle at 30 different sites not only tamed an overactive organ but kept the bladder calm for almost a year, according to Swiss researchers.
Unlike Botox treatments in other muscular disorders or for cosmetic repair, where injections must be repeated at frequent intervals, one injection could provide a long-term cure, Daniel Schmid Jr., M.D., of the University of Zurich reported at the American Urological Association meeting here.
"We were very surprised that we didn't have to re-inject these people after three months or six months," Dr. Schmid said.
Nine months after the initial treatment, 82% of 150 patients, refractory to anticholinergics, who were treated with Botox, were continent, a statistically significant improvement (P<.001 level), Dr. Schmid said. "We can now say that the mean effectiveness of one series of injections is 11 months," he added....At 11 months, 43% of the patients did not require any further treatment, while 23% of the patients have required re-injections. Thirty-one percent of patients have been able to control the return of urgency with anticholinergic drugs...."
[ABSTRACT: CME Teaching Brief - MedPage Today]
"....Botox (botulinum toxin type A) injected directly into the bladder's detrusor muscle at 30 different sites not only tamed an overactive organ but kept the bladder calm for almost a year, according to Swiss researchers.
Unlike Botox treatments in other muscular disorders or for cosmetic repair, where injections must be repeated at frequent intervals, one injection could provide a long-term cure, Daniel Schmid Jr., M.D., of the University of Zurich reported at the American Urological Association meeting here.
"We were very surprised that we didn't have to re-inject these people after three months or six months," Dr. Schmid said.
Nine months after the initial treatment, 82% of 150 patients, refractory to anticholinergics, who were treated with Botox, were continent, a statistically significant improvement (P<.001 level), Dr. Schmid said. "We can now say that the mean effectiveness of one series of injections is 11 months," he added....At 11 months, 43% of the patients did not require any further treatment, while 23% of the patients have required re-injections. Thirty-one percent of patients have been able to control the return of urgency with anticholinergic drugs...."