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Wednesday
Allergies May Precede Parkinson's Disease
Allergies and Parkinson's disease may start out by a common pathway.
An elevated inflammatory response in people with atopic allergic diseases, especially allergic rhinitis, may predispose them to Parkinson's disease later in life, suggested James H. Bower, M.D., of the Mayo Clinic, and colleagues, in the Aug. 8 issue of Neurology.
They compared 196 patients who developed Parkinson's disease over a 20-year period with age- and gender-matched controls, and found that those with what they labeled as immediate-type hypersensitivity (allergies) had a nearly twofold risk for developing Parkinson's overall, the investigators.
Patients with allergic rhinitis had a threefold risk for Parkinson's. In contrast, people who reported regular used of anti-inflammatory drugs, especially ibuprofen, had a significantly lower risk for the disease, pointing to inflammatory processes as a possible cause.
"People with allergic rhinitis mount an immune response with their allergies, so they may be more likely to mount an immune response in the brain as well, which would produce inflammation," Dr. Bower says.
That hypothesis is supported by evidence from other studies of increased microglia and levels of cytokines in the brains of people with Parkinson's, and from other cohort studies suggesting that non-steroidal anti-inflammatory drugs, particularly ibuprofen, are protective against the disease, the authors noted....
Allergies and Parkinson's disease may start out by a common pathway.
An elevated inflammatory response in people with atopic allergic diseases, especially allergic rhinitis, may predispose them to Parkinson's disease later in life, suggested James H. Bower, M.D., of the Mayo Clinic, and colleagues, in the Aug. 8 issue of Neurology.
They compared 196 patients who developed Parkinson's disease over a 20-year period with age- and gender-matched controls, and found that those with what they labeled as immediate-type hypersensitivity (allergies) had a nearly twofold risk for developing Parkinson's overall, the investigators.
Patients with allergic rhinitis had a threefold risk for Parkinson's. In contrast, people who reported regular used of anti-inflammatory drugs, especially ibuprofen, had a significantly lower risk for the disease, pointing to inflammatory processes as a possible cause.
"People with allergic rhinitis mount an immune response with their allergies, so they may be more likely to mount an immune response in the brain as well, which would produce inflammation," Dr. Bower says.
That hypothesis is supported by evidence from other studies of increased microglia and levels of cytokines in the brains of people with Parkinson's, and from other cohort studies suggesting that non-steroidal anti-inflammatory drugs, particularly ibuprofen, are protective against the disease, the authors noted....