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Wednesday
Parkinson's Gene Lowers Age of Onset: "Mutations in a recessive gene that causes early-onset Parkinson's disease also occur in about 12% of those whose families have a familial form of the disease, according to researchers here.
And even carrying a mutation in one copy of the PARK2 gene significantly lowers the age of onset of Parkinson's disease, said to Mei Sun, M.D., Ph.D., of Massachusetts General Hospital and Harvard Medical School.
When both copies of the PARK2 gene are mutated, the gene product parkin is inactivated, resulting in early-onset Parkinson's, Dr. Sun and colleagues reported in the June issue of the Archives of Neurology.
But although the mutations were presumed to be recessive, Dr. Sun and colleagues found, 'there is increasing evidence suggesting that heterozygous mutations may confer increased susceptibility to late-onset Parkinson's....'"
And even carrying a mutation in one copy of the PARK2 gene significantly lowers the age of onset of Parkinson's disease, said to Mei Sun, M.D., Ph.D., of Massachusetts General Hospital and Harvard Medical School.
When both copies of the PARK2 gene are mutated, the gene product parkin is inactivated, resulting in early-onset Parkinson's, Dr. Sun and colleagues reported in the June issue of the Archives of Neurology.
But although the mutations were presumed to be recessive, Dr. Sun and colleagues found, 'there is increasing evidence suggesting that heterozygous mutations may confer increased susceptibility to late-onset Parkinson's....'"