Pramipexole Safe and Effective in Treating Restless Legs Syndrome, Study Shows :
"According to a study published in the journal Neurology, pramipexole significantly improved RLS symptoms in patients with moderate to severe restless legs syndrome (RLS) versus those on placebo, as measured by both of the study's primary efficacy endpoints. Furthermore, therapeutic effects were evident within one week of initiating treatment, and pramipexole demonstrated a favorable safety profile. Significant treatment effects were also apparent for the study's secondary efficacy endpoints, where pramipexole improved ratings of daytime and nighttime symptom severity, as well as sleep satisfaction and quality of life. Primary efficacy endpoints were measured by patient ratings of symptom severity using the International RLS Study Group Rating Scale (IRLS), and clinician ratings of improvement on the Clinical Global Impressions- Improvement Scale (CGI-I). Secondary endpoints for the study included the Patient Global Impression (PGI) responder rate, visual analogue scale (VAS) ratings of sleep, quality of life as measured by the Johns Hopkins Restless Legs Syndrome Qualify of Life (RLS-QOL) questionnaire, and safety....."