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Tuesday
Caffeine Aids Levodopa in Some Parkinson's Patients
Caffeine appears to enhances the bioavailability of levodopa used in treatment of Parkinson's disease, researchers report in the September issue of Neurology.
"Although the study is an evaluation of a single dose of caffeine in a small number of parkinsonian patients, it shows that in certain patients the effect of levodopa may be enhanced following the intake of caffeine," lead investigator Dr. Dirk Deleu told Reuters Health.
Dr. Deleu of Gamad Medical Corporation, Doha, Qatar and colleagues note that there have been mixed reports of the efficacy of this combination. To investigate further, the researchers conducted a double-blind crossover study of 12 patients with idiopathic Parkinson's disease.....
The findings, say the investigators, suggest that caffeine may play a role in dopamine receptor-mediator interactions. These and other results, they add, suggest that more selective adenosine antagonists may be of benefit as synergistc adjuncts to conventional antiparkinsonian agents.
Caffeine appears to enhances the bioavailability of levodopa used in treatment of Parkinson's disease, researchers report in the September issue of Neurology.
"Although the study is an evaluation of a single dose of caffeine in a small number of parkinsonian patients, it shows that in certain patients the effect of levodopa may be enhanced following the intake of caffeine," lead investigator Dr. Dirk Deleu told Reuters Health.
Dr. Deleu of Gamad Medical Corporation, Doha, Qatar and colleagues note that there have been mixed reports of the efficacy of this combination. To investigate further, the researchers conducted a double-blind crossover study of 12 patients with idiopathic Parkinson's disease.....
The findings, say the investigators, suggest that caffeine may play a role in dopamine receptor-mediator interactions. These and other results, they add, suggest that more selective adenosine antagonists may be of benefit as synergistc adjuncts to conventional antiparkinsonian agents.